Brain MRIs Can Be Used to Detect Early Signs of Parkinson’s Cognitive Impairment, Study Suggests

brain MRI

Brain magnetic resonance imaging (MRI) scans could be used to detect early and subtle markers of cognitive impairment in people with Parkinson’s, which may help predict patients’ prognoses and disease progression, a recent study suggests.

Such early detection also allows people with the neurodegenerative disease to start appropriate care strategies earlier, the researchers say.

The results of the study, “Texture features of magnetic resonance images: A marker of slight cognitive deficits in Parkinson’s disease,” were published in the journal Movement Disorders.

Cognitive impairment is a common non-motor symptom of Parkinson’s disease and a cause of significant disability for patients and a burden for caregivers. The extent and progression of cognitive deficits vary, with about 20.3% to 60.5% of individuals experiencing mild cognitive impairments (MCI). In more severe cases, such impairment can result in dementia.
Those at-risk can benefit from early detection of cognitive alterations, which allows them to initiate appropriate care strategies such as cognitive stimulation therapy. Such therapy can result in a marked improvement in cognition and quality of life, according to researchers. However, standard neuropsychological assessments are time-consuming and not easy to do in routine clinical practice. Moreover, such evaluations can be influenced by medication, pain, anxiety, and other factors.
Therefore, additional markers of cognitive deficits are needed for Parkinson’s patients, the researchers say. One potential option is the use of magnetic resonance imaging (MRI), an imaging exam that uses a powerful magnetic field, radio waves, and a computer to produce detailed pictures of the body’s internal structures.
“Texture features” — a well-known method of MRI image processing used for medical purposes — could offer insights on subtle brain changes.  These features could be used to detect the damage to brain cells, long before any symptoms of cognitive impairment develop.
Recognizing the potential of this method, a team of French researchers now tested whether such signals could be used as early markers of Parkinson’s cognitive impairments — “potentially even before the atrophy [loss of brain volume, a usual sign of cognitive decline] becomes manifest,” they said.

The team investigated if MRI texture analysis is sensitive enough to be an early marker of cognitive alterations, specifically of cognitive slowing, in Parkinson’s patients.

They analyzed brain MRI scans of 102 people with Parkinson’s from centers in Lille, France, and Maastricht, the Netherlands, who were involved in a previous study.

Based on tests of attention, memory, executive function, language, and visuospatial functions, three groups of patients were considered for the study. These groups were cognitively intact patients (PDCN); cognitively intact patients with slight cognitive slowing (PDCN-S); and patients with mild cognitive deficits, particularly in executive functioning (PD-EXE).

A group of 17 age‐matched healthy people (controls) was included for comparison. All participants were examined on a 3T whole-body scanner and T1‐weighted images were acquired.

Six regions of the brain previously reported to suffer from atrophy (volume loss) in Parkinson’s patients with cognitive impairments were specifically chosen by the researchers for analysis. These regions were the thalamus, the hippocampus, the puramen, the pallidum, the caudate nucleus, and the amygdala.

The researchers found that values for two texture features — skewness and entropy — could distinguish individuals who had normal cognition from those with slight cognitive slowing, and from those with mild impairments. Skewness is a parameter that quantifies the asymmetry of the intensity of MRI signals. Entropy represents the degree of uncertainty of the texture intensity.

These texture features were at three specific regions in the brain: the hippocampus, the thalamus, and the amygdala.

The values for these features gradually decreased in those patients with worse cognitive function, suggesting it is possible to detect early cognition deficits in people with Parkinson’s using MRIs. The researchers noted that the best performances regarding sensitivity and specificity were obtained by measuring skewness in the hippocampus. In fact, skewness in the hippocampus was a significant marker of slight cognitive slowing.
“Our results suggest that hippocampal neurons could be affected very early in PD patients, even before atrophy can be detected with commonly used methods, and this could cause a general slowing of information processing,” the researchers said.
“These results support the assumption that signal alterations associated with Parkinson’s disease–related cognitive decline can be captured very early by texture analysis,” they added.
The researchers believe that brain MRI imaging could be combined with other methods, such as cognitive assessments and electroencephalograms. That would allow scientists to build a combined model “not only for the profiling but also for the prognosis and the prediction of evolution” of cognitive impairment, they said.

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NIH awards $228,325 to Tech Startup to Develop MRI Device for Improved Diagnosis

MRI scan device

A startup developing a device for more affordable and efficient magnetic resonance imaging (MRI) scans was recently awarded a Small Business Technology Transfer (STTR) grant from the National Institutes of Health.

MR-Link, a technology company affiliated with Purdue University, will receive $228,325 to develop the device. Researchers say it will provide better imaging and promises to improve the diagnosis of Parkinson’s disease and other imaging-diagnosed diseases, while lowering costs and reducing health risks.

“This grant is validation for us that our idea is on the right track and there is a need for these kind of technologies that may help researchers to understand human physiology more accurately,” Ranajay Mandal, one of three MR-Link co-founders and a graduate student at Purdue University’s Weldon School of Biomedical Engineering, said in a press release.

Designed to be inserted into an existing MRI machine, the coin-sized device is synchronized with the MRI system to perform multiple scans at once, allowing researchers to record, stimulate, and image the brain and other organs. By incorporating electro-physiological signals from several organs, the new device promises to more effectively provide insight on a patient’s physiology.

STTR is a highly competitive program that awards federal funding to small businesses and nonprofit institutions to support scientific and technological innovation, and increase private sector commercialization of these innovations.

Out of more than 1,000 applications received from startups throughout the U.S. for Phase 1 STTR grants, only 169 were funded. MR-Link is the only one to receive funding from the state of Indiana, out of 32 that applied.

“We will use this funding to further develop our device and software into a user-friendly system, so that MR-Link can begin to distribute its beta testing units to MRI researchers,” said co-founder Nishant Babaria, a graduate student at the Purdue School of Electrical and Computer Engineering. “We hope to also use the money to enrich our research team with new professionals to help us package the software and hardware.”

MR-Link is reaching out to research facilities first before moving into the clinical market.

“We are open to partnerships with other laboratories and device manufacturers so we could soon deliver devices to more people and to benefit their research and to hopefully soon deliver to clinicians for them to better treat patients,” said co-founder Zhongming Liu, PhD, an assistant professor of electrical and computer engineering and biomedical engineering at Purdue.

The researchers are presenting the device at the upcoming International Society for Magnetic Resonance in Medicine, June 16-21, 2018, in Paris.

MR-Link is opening offices in the Purdue Research Park in West Lafayette, Indiana, the largest university-affiliated business incubation complex in the country.

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Source: Parkinson's News Today