Hypertension May Increase Risk of Parkinson’s, Study Reports

hypertension, Parkinson's risk

Patients with hypertension may be at a higher risk for Parkinson’s disease, according to a review of population-based studies.

The review, “Association between Hypertension and the Risk of Parkinson’s Disease: A Meta-Analysis of Analytical Studies,” appeared in the journal Neuroepidemiology.

Hypertension may cause damage in blood vessels in specific brain areas, such as the basal ganglia, which contain the substantia nigra and the striatum. In Parkinson’s, the substantia nigra experiences progressive loss of dopamine-producing neurons while the striatum has low levels of this neurotransmitter. This suggests a link between hypertension and greater prevalence of Parkinson’s.

However, previous studies have had contradictory findings, with some reporting a greater risk and others suggesting a lower risk for Parkinson’s.

To clarify this link, scientists from Qingdao University in China conducted a meta-analysis — a statistical study that combines the results of various studies — and a systematic review of the available literature.

Seven online databases were searched for literature up to July 13, 2018. From these databases, 27 observational studies were included, nine of which were population-based cohort studies (with a total of 1,230,085 participants) and 18 were case-control studies (32,121 participants). All but one study were from either North America, Europe, or Asia.

Five studies assessed hypertension by medical record, 11 through questionnaire, and two by measuring blood pressure.

In the cohort studies — prospective analyses where groups are followed to compare the risk of a specific outcome — patients with hypertension were at a significantly greater risk for Parkinson’s than participants with normal blood pressure. This was confirmed after excluding the two studies that were leading to high variability of results.

“Based on population-based cohort studies, this meta-analysis indicated hypertension might increase the risk of [Parkinson’s],” the researchers wrote.

In contrast, case-control studies — retrospective analyses where participants with or without hypertension are known from the start — suggested that hypertension might lower the risk for Parkinson’s. However, a subgroup analysis based on non-hospital records revealed no association. The variability observed in these studies was mainly due to different results in controls, depending on whether they were from hospital settings or not.

According to the team, the contradictory results in the two types of studies may have been due to a higher proportion of elderly controls with hypertension in case-control studies, particularly those conducted in the hospital setting.

Due to the link between aging and both hypertension and Parkinson’s, these studies are not suitable for exploring the risk of Parkinson’s in hypertension, the researchers said.

Among the study’s limitations, they mentioned not accounting for the use of anti-hypertensive medications as well as not being able to calculate an overall risk for Parkinson’s combining the two types of studies.

The post Hypertension May Increase Risk of Parkinson’s, Study Reports appeared first on Parkinson’s News Today.

Inflammatory Bowel Disease Linked to Risk of Parkinson’s in Large Review Study

People with inflammatory bowel disease (IBD), an umbrella name for disorders marked by prolonged inflammation of the digestive tract, are at a higher-than-usual risk for Parkinson’s disease, a review study involving 8.9 million IBD patients suggests.
The study, “The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis,” was published in the journal Digestive and Liver Disease.
Inflammatory bowel disease (IBD) is a term that includes two main disorders — ulcerative colitis and Crohn’s disease — and is characterized by an imbalanced immune response that triggers prolonged inflammation of the digestive tract.
Inflammation in ulcerative colitis is confined to the colon (large intestine), while in Crohn’s disease it can involve any part of the digestive system. But inflammation in Crohn’s is most common at the end of the ileum (the last section of the small intestine) or the colon.
Several studies have reported that some of the inflammatory pathways impaired in Parkinson’s are also found in IBD. Certain population-based studies have also reported an increased prevalence of Parkinson’s among IBD patients, but the link between both disorders remains controversial. Another follow-up study failed to confirm those initial findings.
Researchers in China conducted a meta-analysis of published literature focusing on Parkinson’s risk in IBD using two databases, PubMed and Embase, and including in their search the keywords “ulcerative colitis” and “Crohn’s disease.” For the meta-analysis, they included cohort or case-control studies with patients diagnosed with IBD, either ulcerative colitis and Crohn’s disease, and whose main outcome was Parkinson’s.
Out of an initial pool of 172 studies, four studies accounting for a total of more than 8.9 million patients were included in the meta-analysis. (A meta-analysis is a statistical technique used to summarize in a quantitative manner the findings of multiple studies.)
Performed in the United States, Denmark, Sweden and Taiwan, these four studies assessed the incidence rate of Parkinson’s in IBD patients, specifically those with Crohn’s and ulcerative colitis. Three had been conducted in 2018, and one in 2016.
“To our knowledge, this is the first MA [meta-analysis] to focus on the risk of PD [Parkinson’s] in IBD patients,” the research team wrote. “Despite the small number of studies included, the patient numbers were large due to the population-based nature of the included studies.”
Pooled results of all studies suggested that an IBD diagnosis was associated with a 41% increased risk of developing Parkinson’s.
Assessing the risk of ulcerative colitis and Crohn’s disease separately, researchers found that both disease subtypes were linked to a higher Parkinson’s risk compared with age- and sex-matched controls — Crohn’s patients had a 28% higher risk of Parkinson’s, and those with ulcerative colitis a 30% increased risk, the study reported.
Among the IBD patients, the risk for Parkinson’s was not affected by gender, with similar rates seen in male and female patients, or by age.
Overall, this meta-analysis “identified an increased risk of PD in IBD patients,” the reseachers wrote, which “remained significant when separately analysing CD [Crohn’s disease] and UC [ulcerative colitis] subgroups.”
“More comprehensive and detailed MA using a larger number of studies are required to validate our

Source: Parkinson's News Today